Femme et Homme
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Extrait
To compare efficacy and safety of PF 04171327 (1, 5, 10 mg, 15 mg once daily) to 5 mg daily prednisone, 10 mg daily prednisone and placebo given over 8 weeks, in subjects with active RA on a stable background of MTX; Determine comparative therapeutic window of PF 04171327 using ACR 20 responses and change from baseline in P1NP and UNTx/uCr, (primary set of biomarkers) ie, determining a dose, or a range of doses, in which there is sufficient efficacy on the ACR20 and minor changes in P1NP and UNTx/uCr.
Critère d'inclusion
- Rheumatoid Arthritis