Extrait

Background and study aims. This study aimed to examine the acceptability and mechanisms of action of Mindfulness-based Cognitive Therapy (MBCT) delivered to patients in remission, but with a history of serious suicidal thoughts or behaviour. The aim of the study was to explore the feasibility of delivering MBCT to this population, and the extent to which treatment with MBCT could reduce vulnerability to suicidal thoughts and behaviour through an examination of its effects on psychological factors linked to of suicidal vulnerability. Who can participate? Participants aged between 18 and 65 who were currently well but reported at least one prior episode of major depression accompanied by serious suicidal thoughts were recruited from general practitioners and local psychologists/psychiatrists and from the community. All participants were required to be well (no more than one week of minimal depressive symptoms in the past 8 weeks), and to have experienced no episodes of mania for at least 6 months. Additional exclusion criteria included current psychosis, obsessive compulsive disorder or eating disorder as their main problem, current deliberate self harm on a regular basis, a neurological disorder or an inability to complete assessments due to language difficulties or cognitive impairment. What does the study involve? Participants were interviewed using the Mini International Neuropsychiatric Interview to establish psychiatric history. Following this, participants completed a number of other assessment measures assessing aspects of cognitive vulnerability to depression and suicidality. These measures included assessment of residual symptoms of depression, mood-related impairments in problem solving and future thinking, autobiographical memory deficits, tendency to suppress unwanted thoughts and self-discrepancy (perceptions of distance between how one currently sees themselves and how one would like to be). Participants were then randomly allocated to either immediate treatment with MBCT or a waitlist condition. The measures were completed again at the end of treatment or waitlist phase. Following this the waitlist group received treatment with MBCT. What are the possible benefits and risks of participating? Benefits included the fact that all participants were offered treatment with Mindfulness Based Cognitive Therapy, either immediately or at the end of the waitlist phase of the study. Potential risks to participants related to the distress of reporting on prior psychiatric history and the inherent challenges of engaging in a therapeutic process designed to target vulnerability to recurrent depression and suicidality. Where is the study run from? Department of Psychiatry, University of Oxford When is the study starting and how long is it expected to run for? The study started in May 2005 and ended in December 2005 Who is funding the study? The Wellcome Trust Who is the main contact? Professor Mark Williams [email protected]

Critère d'inclusion

• Suicidality

Liens

• isrctn
• ictrp