A study to assess the efficacy and safety of Dupilumab in patients with severe atopic dermatitis (AD) that are not controlled with oral cyclosporine A (CSA) or for those who cannot take oral CSA because it is not medically advisable To evaluate the efficacy of 2 dose regimens of dupilumab compared to placebo, administered with concomitant topical corticosteroids (TCS), in adult patients with severe AD who are not adequately contr...

• Country None
• organs None
• Specialty None

Étude R2810-ONC-16111 : étude de phase 3 randomisée comparant l’efficacité du REGN2810 (cémiplimab) en association avec de l’ipilimumab et celle du REGN2810 en association avec une chimiothérapie à base de platine et de l’ipilimumab avec celle du pembrolizumab en traitement de première ligne chez des patients ayant un cancer du poumon non à petites cellules de stade avancé ou métastatique. [essai clos aux inclusions] Le cancer du poumon se développe à partir de cellules situées dans le poumon qui se sont multipliées de manière anormale pour former une masse ou une tumeur. Le cancer du poumon non à petites cellules...

• Country France
• organs Poumon, type non à petites cellules
• Specialty Immunothérapie - Vaccinothérapie, Chimiothérapie

Efficacy and Safety of REGN727/SAR236553 in patients with primary hypercholesterolemia who are intolerant to statins The primary objective of the study is to demonstrate the reduction of low-density lipoprotein (LDL) cholesterol (LDL-C) by REGN727 in comparison with ezetimibe (EZE) 10 mg PO QD after 24 weeks in pati...

• Country None
• organs None
• Specialty None

A Double-Masked, Randomized, Controlled Study of the Safety, Tolerability and Biological Effect of Repeated Intravitreal Administration of VEGF Trap-Eye in Patients with Diabetic Macular Edema (DME) To explore the effect of various doses and dose intervals of intravitreally (IVT)-administered VEGF Trap-Eye on the best-corrected ETDRS visual acuity (BCVA) in subjects with DME.

• Country None
• organs None
• Specialty None

A study to confirm the efficacy and safety of different dupilumab dose regimens in adults with atopic dermatitis (AD) The primary objective of the study is to assess the ability of different dupilumab dose regimens, administered as monotherapy, to maintain the treatment response achieved after 16 weeks of initial tre...

• Country None
• organs None
• Specialty None

Étude R2810-ONC-1763 : étude de phase 2 randomisée comparant du cemiplimab à dose élevée et standard par rapport au cemiplimab à dose standard en association avec de l ’ipilimumab chez des patients ayant un cancer du poumon métastatique non à petites cellules précédemment traité par un traitement de deuxième intention. [essai clos aux inclusions] Le cancer du poumon se développe à partir de cellules situées dans le poumon et qui se sont multipliées de manière anormale pour former une masse ou une tumeur. Le cancer du poumon non à petites cellu...

• Country France
• organs Poumon, type non à petites cellules
• Specialty Immunothérapie - Vaccinothérapie

A study to determine the long-term safety and the efficacy of fasinumab for treatment of adults with pain from osteoarthritis of the knee or hip To evaluate the long-term joit safety of fasinumab compared with placebo when administered in patients with pain due to radiographically confirmed OA in the knee or hip

• Country None
• organs None
• Specialty None

A Multi-Center, Randomized, Double-Blind, Placebo Controlled Study of the Efficacy and Safety of Rilonacept for the Prophylaxis of Gout Flares During the Initiation of Allopurinol Therapy To determine the efficacy of 160 mg and 80 mg of subcutaneous (SC) rilonacept therapy compared to placebo in the prophylaxis of flares in subjects with intercritical gout initiating therapy with allop...

• Country None
• organs None
• Specialty None

A study to assess the long-term safety and efficacy of dupilumab administered in patients 6 to <18 year of age with atopic dermatitis (eczema) The primary objective of the study is to assess the long-term safety of dupilumab in pediatric patients with AD.

• Country None
• organs None
• Specialty None

A study to see if multiple doses of REGN668 given by injections under the skin is effective, safe and how it acts in the body of adult patients with moderate-to-severe atopic dermatitis caused by allergic response The primary objective is to assess the clinical efficacy of repeated subcutaneous (SC) doses of REGN668 in adult patients with moderate-to-severe atopic dermatitis (AD).

• Country None
• organs None
• Specialty None