Using Patient Reported Outcomes (PROs) to Evaluate Teriflunomide Treatment in Relapsing Multiple Sclerosis (RMS) Patients To describe efficacy, tolerability and convenience of teriflunomide treatment through the evaluation of PROs

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Genzyme CAM203 : Essai de 2 randomisé en escalade de dose évaluant l’efficacité et la tolérance d’un traitement par injection sous cutanée d’alemtuzumab chez des patients ayant une leucémie chronique lymphocytaire à grandes cellules B. [Informations issues du site clinicaltrials.gov et traduites par l'INCa] [essai clos aux inclusions] A phase II trial to evaluate the efficacy and safety of subcutaneously administered alemtuzumab (campath®, mabcampath®) in patients with previously treated B-cell chronic lymphocytic leukemia.

• Pays France
• Organes Leucémies chroniques
• Spécialités Thérapies Ciblées

Safety, Efficacy, and Pharmacokinetics Study of Recombinant Human Acid Sphingomyelinase in Patients With Acid Sphingomyelinase Deficiency Sicurezza, Efficacia e Analisi di Farmacocinetica della sfingomielinasi acida ricombinante umana in pazienti con carenza di sfingomielinasi acida The primary objective is to evaluate the safety, efficacy, and pharmacokinetics of different doses of rhASM administered intravenously (IV) every 2 weeks for 52 weeks. L’obiettivo primario di...

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Efficacy, Safety and Pharmacokinetics of Teriflunomide in Pediatric Patients with Relapsing Forms of Multiple Sclerosis To assess the effect of teriflunomide in comparison to placebo on disease activity measured by time to first clinical relapse after randomization in children and adolescents 10 to 17 years of age with...

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Genzyme CAM314 : Essai de phase 3 randomisé comparant l’efficacité et la tolérance de fludarabine associé ou non à alemtuzumab en traitement de 2nd ligne chez des patients ayant une leucémie chronique lymphocytaire à grandes cellules B. [Informations issues du site clinicaltrials.gov et traduites par l'INCa] [essai clos aux inclusions] Phase III randomized trial to evaluate the efficacy and safety of second-line therapy with fludara plus alemtuzumab (campath, mabcampath) versus fludara alone in patients with B-cell chronic lymphocyt...

• Pays France
• Organes Leucémies chroniques
• Spécialités Chimiothérapie, Thérapies Ciblées

A Study of the Safety and Efficacy of Two Different Regimens of Mipomersen in Patients With Familial Hypercholesterolemia and Inadequately Controlled Low-Density Lipoprotein Cholesterol Determine whether mipomersen (ISIS 301012) significantly reduces atherogenic lipid levels in patients with severe heterozygous familial hypercholesterolemia (severe HeFH), defined as low-density lipop...

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An Open-Label Extension Study of Patients with Late-Onset Pompe Disease Who Were Previously Enrolled in Protocol AGLU02704 The objective of this extension study is to assess the long-term safety and efficacy of Myozyme treatment in patients with Late-Onset Pompe Disease who were previously treated under the placebo-contro...

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GZ/SAR402671 in Combination with Cerezyme in Adult Patients with Gaucher Disease Type 3 Part 1: -Evaluate central nervous system (CNS) biomarkers in Gaucher disease (GD) type 3 (GD3) that distinguish GD3 from Gaucher disease type 1 (GD1). -Screen adult GD3 patients who qualify for trea...

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Multifactorial Approach and Superior Treatment Efficacy in Renal Patients with the Aid of Nurse practitioners Not provided at time of registration

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Phase III Randomized, Double-Blind, Controlled Study Comparing Clofarabine and Cytarabine versus Cytarabine Alone in Adult Patients 55 Years and Older with Acute Myelogenous Leukemia (AML) who have Relapsed or are Refractory after Receiving up to Two Prior Induction Regimens To assess the efficacy of clofarabine in combination with cytarabine compared with cytarabine alone in adult patients 55 years and older with AML who have either relapsed or are refractory after recei...

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