The purpose of this study is to find out more about romosozumab in women with postmenopausal osteoporosis. This study will see if romosozumab, given in two different forms, increases bone mineral density and whether it causes any side effects. To do this, romosozumab at one concentration and in one type of syringe will be compared to romosozumab at another concentration and in another type of syringe To evaluate the noninferiority of a 6-month treatment with 210 mg romosozumab administered every month (QM) using a 90 mg/mL concentration compared with 210 mg romosozumab QM using a 70 mg/mL concentr...

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Study to assess the tolerability and efficacy of AMG 145 in patients with hypercholesterolemia unable to tolerate an effective dose of a statin To evaluate the effect of 12 weeks of subcutaneous (SC) AMG 145, compared with ezetimibe, on percent change from baseline in low-density lipoprotein cholesterol (LDL-C) in hypercholesterolemic subject...

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A study to look at the effect of AMG 145 on the build up of a waxy substance (plaque) in the arteries of the heart, using a method to see inside the heart To evaluate the effect of AMG 145 on the change in burden of coronary atherosclerosis as measured by percent atheroma volume (PAV) in patients with coronary artery disease requiring angiography for a ...

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Study of the bioavailability of cinacalcet capsules compared to the approved cinacalcet tablets The primary objective of this study is to evaluate the comparative bioavailability based on AUC0-inf, AUC0-t, and Cmax, between six of the 5 mg capsules of cinacalcet swallowed whole with applesauce, ...

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A Study of the Effects of AMG 334 to Prevent Migraine Headaches To evaluate the effect of AMG 334 compared to placebo on the change from baseline in monthly migraine days, in subjects with chronic migraine

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A study of AMG 416 in the treatment of secondary hyperparathyroidism in chronic kidney disease To characterize the long-term safety and tolerability of AMG 416 in the treatment of SHPT in subjects with chronic kidney disease on hemodialysis.

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Comparison of survival benefit of panitumumab with supportive care to best supportive care alone in patients with metastatic colorectal cancer To evaluate the effect of panitumumab and best supportive care (BSC) versus BSC alone on overall survival (OS) in subjects with chemorefractory wild-type codons 12 and 13 Kirsten rat sarcoma viral onc...

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A Randomized Open-Label Study of Darbepoetin alfa Administered Every Three Weeks with or without Parenteral Iron in Anemic Subjects with Nonmyeloid Malignancies Receiving Chemotherapy To compare hematopoietic response after 16 weeks of treatment with 500 mcg once every 3 weeks (Q3W) darbepoetin alfa and either IV iron or following standard practice (oral iron or no iron supplementa...

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Study designed to evaluate the safety and efficacy of AMG 145 compared with Ezetimibe treatment, in people with high cholesterol who have experienced side effects whilst taking existing statin treatment Studio per valutare l’efficacia e la sicurezza di AMG 145 rispetto rispetto al trattamento con ezetimibe, in soggetti con elevati livelli di colesterolo che hanno avuto effetti indesiderati durante il trattamento con statine To evaluate the effect of AMG 145 administered subcutaneously (SC) once every month (QM) compared with ezetimibe (Part B), on percent change from baseline in low-density lipoprotein cholesterol (LDL-C...

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A study of AMG 386 or placebo in combination with paclitaxel and carboplatin to treat ovarian cancer Μια μελέτη με AMG 386 ή εικονικού φαρμάκου σε συνδυασμό με πακλιξατέλη και καρβοπλατίνη για τη θεραπεία του καρκίνου των ωοθηκών To determine if 6 cycles of paclitaxel and carboplatin plus AMG 386 followed by 18 months of AMG 386 maintenance improves progression-free survival (PFS) compared to 6 cycles of paclitaxel and carbopl...

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